[An association between the FABP2 gene polymorphism and efficacy of valproates] Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov [Zh Nevrol Psikhiatr Im S S Korsakova] Journal article | | Title | [An association between the FABP2 gene polymorphism and efficacy of valproates] | | Source | Zh Nevrol Psikhiatr Im S S Korsakova 2007; 107(1):42-5. | | Abstract | To search for association between the 163G>A polymorphism of the fatty acid binding protein 2 (FABP2) gene and intracellular transport of the valproic acid in the small intestines, 168 patients with different forms of epilepsy, aged from 1 to 89 years, and different illness duration have been studied. The patients received valproates (127 patients) and topiramate (41 patients) as a monotherapy. It has been shown that the 163G>A (Ala54Thr) polymorphism exerts an influence on effective dose of the valproic acid but not of topiramate. | | Language | rus | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 17310796 |
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